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Axin1 mutations have been reported to account for approximately 3%-16% of all HCC cases, and Axin2 for approximately 3% (67)

Current evidence, including magnetic resonance imaging studies, suggests that skeletal muscle alterations resulting from GLP-1 RA-induced weight loss, such as enhanced insulin sensitivity and reduced muscle fat infiltration, are adaptive, thereby improving muscle quality despite concurrent reductions in lean mass [112]